Structure-function relationships in the IL-17 receptor: implications for signal transduction and therapy.
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ABSTRACT:
SUBMITTER: Shen F
PROVIDER: S-EPMC2667118 | biostudies-literature | 2008 Feb
REPOSITORIES: biostudies-literature
Publications
Structure-function relationships in the IL-17 receptor: implications for signal transduction and therapy.
Cytokine 20080104 2
IL-17 is the defining cytokine of a newly-described "Th17" population that plays critical roles in mediating inflammation and autoimmunity. The IL-17/IL-17 receptor superfamily is the most recent class of cytokines and receptors to be described, and until recently very little was known about its function or molecular biology. However, in the last year important new insights into the composition and dynamics of the receptor complex and mechanisms of downstream signal transduction have been made, ...[more]
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