Ontology highlight
ABSTRACT:
SUBMITTER: Zhao C
PROVIDER: S-EPMC2667220 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Nature structural & molecular biology 20090329 4
MicroRNAs have been implicated as having important roles in stem cell biology. MicroRNA-9 (miR-9) is expressed specifically in neurogenic areas of the brain and may be involved in neural stem cell self-renewal and differentiation. We showed previously that the nuclear receptor TLX is an essential regulator of neural stem cell self-renewal. Here we show that miR-9 suppresses TLX expression to negatively regulate neural stem cell proliferation and accelerate neural differentiation. Introducing a T ...[more]