Ontology highlight
ABSTRACT:
SUBMITTER: Yang XJ
PROVIDER: S-EPMC2667380 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Yang Xiang-Jiao XJ Seto Edward E
Nature reviews. Molecular cell biology 20080301 3
Protein lysine deacetylases have a pivotal role in numerous biological processes and can be divided into the Rpd3/Hda1 and sirtuin families, each having members in diverse organisms including prokaryotes. In vertebrates, the Rpd3/Hda1 family contains 11 members, traditionally referred to as histone deacetylases (HDAC) 1-11, which are further grouped into classes I, II and IV. Whereas most class I HDACs are subunits of multiprotein nuclear complexes that are crucial for transcriptional repression ...[more]