Ontology highlight
ABSTRACT:
SUBMITTER: Visintin R
PROVIDER: S-EPMC266767 | biostudies-literature | 2003 Nov
REPOSITORIES: biostudies-literature
Visintin Rosella R Stegmeier Frank F Amon Angelika A
Molecular biology of the cell 20030807 11
In budding yeast, the protein phosphatase Cdc14 controls exit from mitosis. Its activity is regulated by a competitive inhibitor Cfi1/Net1, which binds to and sequesters Cdc14 in the nucleolus. During anaphase, Cdc14 is released from its inhibitor by the action of two regulatory networks. The Cdc Fourteen Early Anaphase Release (FEAR) network initiates Cdc14 release from Cfi1/Net1 during early anaphase, and the Mitotic Exit Network (MEN) promotes Cdc14 release during late anaphase. Here, we inve ...[more]