Ontology highlight
ABSTRACT:
SUBMITTER: Pearce MM
PROVIDER: S-EPMC2667730 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Pearce Margaret M P MM Wormer Duncan B DB Wilkens Stephan S Wojcikiewicz Richard J H RJ
The Journal of biological chemistry 20090224 16
How endoplasmic reticulum (ER) proteins that are substrates for the ER-associated degradation (ERAD) pathway are recognized for polyubiquitination and proteasomal degradation is largely unresolved. Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) form tetrameric calcium channels in ER membranes, whose primary role is to control the release of ER calcium stores, but whose levels are also regulated, in an activation-dependent manner, by the ERAD pathway. Here we report that the ER membrane protein ...[more]