Ontology highlight
ABSTRACT:
SUBMITTER: Vasilatos SN
PROVIDER: S-EPMC2667866 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Vasilatos Shauna N SN Broadwater Gloria G Barry William T WT Baker Joseph C JC Lem Siya S Dietze Eric C EC Bean Gregory R GR Bryson Andrew D AD Pilie Patrick G PG Goldenberg Vanessa V Skaar David D Paisie Carolyn C Torres-Hernandez Alejandro A Grant Tracey L TL Wilke Lee G LG Ibarra-Drendall Catherine C Ostrander Julie H JH D'Amato Nicholas C NC Zalles Carola C Jirtle Randy R Weaver Valerie M VM Seewaldt Victoria L VL
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20090303 3
<h4>Background</h4>Only 5% of all breast cancers are the result of BRCA1/2 mutations. Methylation silencing of tumor suppressor genes is well described in sporadic breast cancer; however, its role in familial breast cancer is not known.<h4>Methods</h4>CpG island promoter methylation was tested in the initial random periareolar fine-needle aspiration sample from 109 asymptomatic women at high risk for breast cancer. Promoter methylation targets included RARB (M3 and M4), ESR1, INK4a/ARF, BRCA1, P ...[more]