Roles of BCCIP in chromosome stability and cytokinesis.
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ABSTRACT:
SUBMITTER: Meng X
PROVIDER: S-EPMC2667889 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Publications
Roles of BCCIP in chromosome stability and cytokinesis.
Oncogene 20070423 43
The BRCA2 gene is involved in recombinational DNA repair and cytokinesis. BRCA2 defects are associated with chromosomal abnormalities, which is a hallmark of genomic instability that contributes to tumorigenesis. Here, we show that downregulation of a BRCA2 interacting protein (BCCIP) in HT1080 cells leads to chromosomal polyploidization, centrosome amplification and abnormal mitotic spindle formation. The BCCIP knockdown cells can enter mitosis and retain spindle checkpoint, but fail to complet ...[more]
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