Ontology highlight
ABSTRACT:
SUBMITTER: Rosa-Rosa JM
PROVIDER: S-EPMC2668009 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Rosa-Rosa Juan Manuel JM Pita Guillermo G Urioste Miguel M Llort Gemma G Brunet Joan J Lázaro Conxi C Blanco Ignacio I Ramón y Cajal Teresa T Díez Orland O de la Hoya Miguel M Caldés Trinidad T Tejada Maria-Isabel MI González-Neira Anna A Benítez Javier J
American journal of human genetics 20090115 2
Despite all the research efforts made during the last few decades, most of the cases of families with breast cancer remain unexplained. Mutations in BRCA1 and BRCA2, and in other breast-cancer-susceptibility genes, account for about 25% of familial breast cancer. Linkage studies have failed to identify other breast-cancer-susceptibility genes. The selection criteria of the families, differences in the population background, or clinical and genetic heterogeneity, among other factors, might determ ...[more]