Low Allele Frequency of ADH1B∗47His in West China and Different ADH1B Haplotypes in Western and Eastern Asia
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ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC2668049 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
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Project description:The ADH1B Arg47His polymorphism has been convincingly associated with alcoholism in numerous studies of several populations in Asia and Europe. In a review of literature from the past 30 years, we have identified studies that report allele frequencies of this polymorphism for 131 population samples from many different parts of the world. The derived ADH1B*47His allele reaches high frequencies only in western and eastern Asia. To pursue this pattern, we report here new frequency data for 37 populations. Most of our data are from South and Southeast Asia and confirm that there is a low frequency of this allele in the region between eastern and western Asia. The distribution suggests that the derived allele increased in frequency independently in western and eastern Asia after humans had spread across Eurasia.
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Project description:Gastritis results from multifactorial gastric mucosal injury. Helicobacter pylori (Hp) is the main cause, and associated diseases have typical underlying patterns of gastritis. Gastric ulcer and gastric cancer (GC) develop from chronic atrophic corpus gastritis (CAG) which therefore represents the most important pattern. GC incidences in East Asia are substantially higher than elsewhere, and this should be also reflected by higher prevalences of CAG and characteristic differences in pathophysiology compared to the West.The few available comparative studies of gastritis in Eastern and Western patients are summarized. The main pathogenic factors of gastritis are discussed together with their limitations to explain local differences in disease outcome. Emphasis was put to also include less well-established pathogenic host and environmental factors of possible impact.CAG is more prevalent in East Asian areas with high GC incidences than the West. Geographic heterogeneity of associated diseases is due to differences in Hp prevalence and virulence as well as modulating host and environmental factors. The following may contribute to the higher burden of CAG in the East: ABD type of CagA with vacA s1 and babA2 alleles of Hp, host Lewis(b) expression in sej/sej nonsecretors, H. heilmannii, low parietal cell mass, high sodium and nitrate intake, preferences in vegetable and fruit consumption, cigarette smoking, air pollution, alcohol. Conversely, green tea, nonfermented soy products and rice may confer protective effects. Hp is on the decline, but also in a world cleared from this bacterium, differences in host genetics will continue to modify gastric disease outcome together with maintained customs as part of cultural diversity.
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Project description:Across the distribution of the Caspian whipsnake (Dolichophis caspius), populations have become increasingly disconnected due to habitat alteration. To understand population dynamics and this widespread but locally endangered snake's adaptive potential, we investigated population structure, admixture, and effective migration patterns. We took a landscape-genomic approach to identify selected genotypes associated with environmental variables relevant to D. caspius. With double-digest restriction-site associated DNA (ddRAD) sequencing of 53 samples resulting in 17,518 single nucleotide polymorphisms (SNPs), we identified 8 clusters within D. caspius reflecting complex evolutionary patterns of the species. Estimated Effective Migration Surfaces (EEMS) revealed higher-than-average gene flow in most of the Balkan Peninsula and lower-than-average gene flow along the middle section of the Danube River. Landscape genomic analysis identified 751 selected genotypes correlated with 7 climatic variables. Isothermality correlated with the highest number of selected genotypes (478) located in 41 genes, followed by annual range (127) and annual mean temperature (87). We conclude that environmental variables, especially the day-to-night temperature oscillation in comparison to the summer-to-winter oscillation, may have an important role in the distribution and adaptation of D. caspius.
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Project description:The ability to migrate is an important biological trait of insects, and wingbeat frequency (WBF) is a key factor influencing migratory behavior. The WBF of insects has been shown to be species-specific in previous studies; however, there is scant information on variations in WBF among different taxa of migratory insects. In 2018 and 2019, we investigated the relationship between WBF and 12 morphological variables (e.g., body mass, body length, total wing area, etc.) of the main migratory insects (77 species in 3 orders and 14 families) over the Bohai Sea in China. The WBF of migratory insects was negatively correlated with the 12 morphological variables and varied significantly among orders. In migratory lepidopterans, neuropterans, and odonatans, the ranges of WBF were 6.71-81.28 Hz, 19.17-30.53 Hz, and 18.35-38.01 Hz, respectively. Regression models between WBF and connecting morphological variables were established for these three orders. Our findings revealed the relationship between WBF and morphometrics of migratory insects in Northeast Asia, increased our knowledge on the flight biology of migratory insects, and provided a basis for developing morphological and WBF-based monitoring techniques to identify migrating insects.
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Project description:Organisation EGAO00000001176
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