Ontology highlight
ABSTRACT:
SUBMITTER: He B
PROVIDER: S-EPMC2668055 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
He Bing B Osterholm Anne-May AM Hoverfält Anna A Forsblom Carol C Hjörleifsdóttir Eyrún Edda EE Nilsson Ann-Sofie AS Parkkonen Maikki M Pitkäniemi Janne J Hreidarsson Astrádur A Sarti Cinzia C McKnight Amy Jayne AJ Maxwell A Peter AP Tuomilehto Jaakko J Groop Per-Henrik PH Tryggvason Karl K
American journal of human genetics 20081211 1
Diabetic nephropathy (DN) is the primary cause of morbidity and mortality in patients with type 1 diabetes mellitus (T1DM) and affects about 30% of these patients. We have previously localized a DN locus on chromosome 3q with suggestive linkage in Finnish individuals. Linkage to this region has also been reported earlier by several other groups. To fine map this locus, we conducted a multistage case-control association study in T1DM patients, comprising 1822 cases with nephropathy and 1874 T1DM ...[more]