Ontology highlight
ABSTRACT:
SUBMITTER: Greco V
PROVIDER: S-EPMC2668200 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Greco Valentina V Chen Ting T Rendl Michael M Schober Markus M Pasolli H Amalia HA Stokes Nicole N Dela Cruz-Racelis June J Fuchs Elaine E
Cell stem cell 20090201 2
Hair follicles (HFs) undergo cyclic bouts of degeneration, rest, and regeneration. During rest (telogen), the hair germ (HG) appears as a small cell cluster between the slow-cycling bulge and dermal papilla (DP). Here we show that HG cells are derived from bulge stem cells (SCs) but become responsive quicker to DP-promoting signals. In vitro, HG cells also proliferate sooner but display shorter-lived potential than bulge cells. Molecularly, they more closely resemble activated bulge rather than ...[more]