Ontology highlight
ABSTRACT:
SUBMITTER: Stehouwer JS
PROVIDER: S-EPMC2668213 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Stehouwer Jeffrey S JS Jarkas Nachwa N Zeng Fanxing F Voll Ronald J RJ Williams Larry L Camp Vernon M VM Malveaux Eugene J EJ Votaw John R JR Howell Leonard L Owens Michael J MJ Goodman Mark M MM
Journal of medicinal chemistry 20081201 24
The meta-vinylhalide fluoroalkyl ester nortropanes 1-4 were synthesized as ligands of the serotonin transporter (SERT) for use as positron emission tomography (PET) imaging agents. In vitro competition binding assays demonstrated that 1-4 have a high affinity for the SERT (K(i) values = 0.3-0.4 nM) and are selective for the SERT over the dopamine and norepinephrine transporters (DAT and NET). MicroPET imaging in anesthetized cynomolgus monkeys with [(18)F]1-[(18)F]4 demonstrated that all four tr ...[more]