Dataset Information

Variable nucleotide tandem-repeat analysis revealing a unique group of Leptospira interrogans serovar Pomona isolates associated with California sea lions.

ABSTRACT: Leptospira interrogans serovar Pomona isolates were compared by variable nucleotide tandem-repeat typing. Most cattle isolates grouped together, while isolates from pigs and wildlife were distributed across several groups. Significantly, California sea lion isolates formed a unique group, providing evidence that these animals are maintenance hosts of serovar Pomona.

SUBMITTER: Zuerner RL

PROVIDER: S-EPMC2668322 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Variable nucleotide tandem-repeat analysis revealing a unique group of Leptospira interrogans serovar Pomona isolates associated with California sea lions.

Zuerner Richard L RL Alt David P DP

Journal of clinical microbiology 20090209 4

Leptospira interrogans serovar Pomona isolates were compared by variable nucleotide tandem-repeat typing. Most cattle isolates grouped together, while isolates from pigs and wildlife were distributed across several groups. Significantly, California sea lion isolates formed a unique group, providing evidence that these animals are maintenance hosts of serovar Pomona. ...[more]

PMID: 19204099

Similar Datasets

Project description:Identifying mechanisms driving pathogen persistence is a vital component of wildlife disease ecology and control. Asymptomatic, chronically infected individuals are an oft-cited potential reservoir of infection, but demonstrations of the importance of chronic shedding to pathogen persistence at the population-level remain scarce. Studying chronic shedding using commonly collected disease data is hampered by numerous challenges, including short-term surveillance that focuses on single epidemics and acutely ill individuals, the subtle dynamical influence of chronic shedding relative to more obvious epidemic drivers, and poor ability to differentiate between the effects of population prevalence of chronic shedding vs. intensity and duration of chronic shedding in individuals. We use chronic shedding of Leptospira interrogans serovar Pomona in California sea lions (Zalophus californianus) as a case study to illustrate how these challenges can be addressed. Using leptospirosis-induced strands as a measure of disease incidence, we fit models with and without chronic shedding, and with different seasonal drivers, to determine the time-scale over which chronic shedding is detectable and the interactions between chronic shedding and seasonal drivers needed to explain persistence and outbreak patterns. Chronic shedding can enable persistence of L. interrogans within the sea lion population. However, the importance of chronic shedding was only apparent when surveillance data included at least two outbreaks and the intervening inter-epidemic trough during which fadeout of transmission was most likely. Seasonal transmission, as opposed to seasonal recruitment of susceptibles, was the dominant driver of seasonality in this system, and both seasonal factors had limited impact on long-term pathogen persistence. We show that the temporal extent of surveillance data can have a dramatic impact on inferences about population processes, where the failure to identify both short- and long-term ecological drivers can have cascading impacts on understanding higher order ecological phenomena, such as pathogen persistence.

Dataset Information

Variable nucleotide tandem-repeat analysis revealing a unique group of Leptospira interrogans serovar Pomona isolates associated with California sea lions.

Publications

Variable nucleotide tandem-repeat analysis revealing a unique group of Leptospira interrogans serovar Pomona isolates associated with California sea lions.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets