The Rv1712 Locus from Mycobacterium tuberculosis H37Rv codes for a functional CMP kinase that preferentially phosphorylates dCMP.
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ABSTRACT:
SUBMITTER: Thum C
PROVIDER: S-EPMC2668428 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
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The Rv1712 Locus from Mycobacterium tuberculosis H37Rv codes for a functional CMP kinase that preferentially phosphorylates dCMP.
Thum Caroline C Schneider Cristopher Z CZ Palma Mario S MS Santos Diógenes S DS Basso Luiz A LA
Journal of bacteriology 20090130 8
The Mycobacterium tuberculosis cmk gene, predicted to encode a CMP kinase (CMK), was cloned and expressed, and its product was purified to homogeneity. Steady-state kinetics confirmed that M. tuberculosis CMK is a monomer that preferentially phosphorylates CMP and dCMP by a sequential mechanism. A plausible role for CMK is discussed. ...[more]
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