Artificial enzymes with thiazolium and imidazolium coenzyme mimics.
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ABSTRACT:
SUBMITTER: Zhao H
PROVIDER: S-EPMC2668524 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Publications
Artificial enzymes with thiazolium and imidazolium coenzyme mimics.
Zhao Huanyu H Foss Frank W FW Breslow Ronald R
Journal of the American Chemical Society 20080903 38
Hydrophobic thiazolium and imidazolium coenzyme mimics in the presence of modified-polyethylenimine enzyme mimics catalyze the benzoin condensation 2300-3300 times faster than the coenzyme mimics alone. Polycationic enzyme mimics provide not only a hydrophobic binding domain for coenzyme and substrate, but also electrostatic stabilization of anionic species that arise along the reaction pathway of the benzoin condensation. ...[more]
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