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Use of 5-alpha-reductase inhibitors for prostate cancer chemoprevention: American Society of Clinical Oncology/American Urological Association 2008 Clinical Practice Guideline.


ABSTRACT: PURPOSE To develop an evidence-based guideline on the use of 5-alpha-reductase inhibitors (5-ARIs) for prostate cancer chemoprevention. METHODS The American Society of Clinical Oncology (ASCO) Health Services Committee (HSC), ASCO Cancer Prevention Committee, and the American Urological Association Practice Guidelines Committee jointly convened a Panel of experts, who used the results from a systematic review of the literature to develop evidence-based recommendations on the use of 5-ARIs for prostate cancer chemoprevention. Results The systematic review completed for this guideline identified 15 randomized clinical trials that met the inclusion criteria, nine of which reported prostate cancer period prevalence. CONCLUSION Asymptomatic men with a prostate-specific antigen (PSA)

SUBMITTER: Kramer BS 

PROVIDER: S-EPMC2668556 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature

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Use of 5-alpha-reductase inhibitors for prostate cancer chemoprevention: American Society of Clinical Oncology/American Urological Association 2008 Clinical Practice Guideline.

Kramer Barnett S BS   Hagerty Karen L KL   Justman Stewart S   Somerfield Mark R MR   Albertsen Peter C PC   Blot William J WJ   Ballentine Carter H H   Costantino Joseph P JP   Epstein Jonathan I JI   Godley Paul A PA   Harris Russell P RP   Wilt Timothy J TJ   Wittes Janet J   Zon Robin R   Schellhammer Paul P  

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090224 9


PURPOSE To develop an evidence-based guideline on the use of 5-alpha-reductase inhibitors (5-ARIs) for prostate cancer chemoprevention. METHODS The American Society of Clinical Oncology (ASCO) Health Services Committee (HSC), ASCO Cancer Prevention Committee, and the American Urological Association Practice Guidelines Committee jointly convened a Panel of experts, who used the results from a systematic review of the literature to develop evidence-based recommendations on the use of 5-ARIs for pr  ...[more]

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