Actin bundling: initiation mechanisms and kinetics.
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ABSTRACT:
SUBMITTER: Kraikivski P
PROVIDER: S-EPMC2668770 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Publications
Actin bundling: initiation mechanisms and kinetics.
Kraikivski Pavel P Slepchenko Boris M BM Novak Igor L IL
Physical review letters 20080917 12
Bundling of rapidly polymerizing actin filaments underlies the dynamics of filopodial protrusions that play an important role in cell migration and cell-cell interaction. Recently, the formation of actin bundles has been reconstituted in vitro, and two scenarios of bundle initiation, involving binding of two filament tips and, alternatively, linking of the tip of one filament to the side of the other, have been discussed. A first theoretical analysis is presented indicating that the two mechanis ...[more]
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