Developmental acquisition of sensory transduction in hair cells of the mouse inner ear.
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ABSTRACT:
SUBMITTER: Geleoc GS
PROVIDER: S-EPMC2669437 | biostudies-literature | 2003 Oct
REPOSITORIES: biostudies-literature
Publications
Developmental acquisition of sensory transduction in hair cells of the mouse inner ear.
Géléoc Gwénaëlle S G GS Holt Jeffrey R JR
Nature neuroscience 20030914 10
Sensory transduction in hair cells requires assembly of membrane-bound transduction channels, extracellular tip-links and intracellular adaptation motors with sufficient precision to confer nanometer displacement sensitivity. Here we present evidence based on FM1-43 fluorescence, scanning electron microscopy and RT-PCR that these three essential elements are acquired concurrently between embryonic day 16 and 17, several days after the appearance of hair bundles, and that their acquisition coinci ...[more]
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