Ontology highlight
ABSTRACT:
SUBMITTER: Oshima M
PROVIDER: S-EPMC2670107 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Oshima Motohiko M Mimura Junsei J Sekine Hiroki H Okawa Hiromi H Fujii-Kuriyama Yoshiaki Y
The Journal of biological chemistry 20090227 17
The aryl hydrocarbon receptor (AhR) repressor (AhRR) inhibits the AhR activity. AhRR acts by competing with AhR for heterodimer formation with the AhR nuclear translocator (Arnt) and preventing the AhR.Arnt complex from binding the xenobiotic-responsive elements. Here, we report that AhRR has three evolutionarily conserved SUMOylation consensus sequences within its C-terminal repression domain and that Lys-542, Lys-583, and Lys-660 at the SUMOylation sites are modified by SUMO-1 in vivo. Arginin ...[more]