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Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype.

ABSTRACT: A key challenge in radiotherapy is to maximize radiation doses to cancer cells while minimizing damage to surrounding healthy tissue. As severe toxicity in a minority of patients limits the doses that can be safely given to the majority, there is interest in developing a test to measure an individual's radiosensitivity before treatment. Variation in sensitivity to radiation is an inherited genetic trait and recent progress in genotyping raises the possibility of genome-wide studies to characterize genetic profiles that predict patient response to radiotherapy.

SUBMITTER: Barnett GC 

PROVIDER: S-EPMC2670578 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature

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Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype.

Barnett Gillian C GC   West Catherine M L CM   Dunning Alison M AM   Elliott Rebecca M RM   Coles Charlotte E CE   Pharoah Paul D P PD   Burnet Neil G NG  

Nature reviews. Cancer 20090116 2

A key challenge in radiotherapy is to maximize radiation doses to cancer cells while minimizing damage to surrounding healthy tissue. As severe toxicity in a minority of patients limits the doses that can be safely given to the majority, there is interest in developing a test to measure an individual's radiosensitivity before treatment. Variation in sensitivity to radiation is an inherited genetic trait and recent progress in genotyping raises the possibility of genome-wide studies to characteri  ...[more]