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Increased expression of receptors for orexigenic factors in nodose ganglion of diet-induced obese rats.


ABSTRACT: The vagal afferent pathway is important in short-term regulation of food intake, and decreased activation of this neural pathway with long-term ingestion of a high-fat diet may contribute to hyperphagic weight gain. We tested the hypothesis that expression of genes encoding receptors for orexigenic factors in vagal afferent neurons are increased by long-term ingestion of a high-fat diet, thus supporting orexigenic signals from the gut. Obesity-prone (DIO-P) rats fed a high-fat diet showed increased body weight and hyperleptinemia compared with low-fat diet-fed controls and high-fat diet-induced obesity-resistant (DIO-R) rats. Expression of the type I cannabinoid receptor and growth hormone secretagogue receptor 1a in the nodose ganglia was increased in DIO-P compared with low-fat diet-fed controls or DIO-R rats. Shifts in the balance between orexigenic and anorexigenic signals within the vagal afferent pathway may influence food intake and body weight gain induced by high fat diets.

SUBMITTER: Paulino G 

PROVIDER: S-EPMC2670626 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature

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Increased expression of receptors for orexigenic factors in nodose ganglion of diet-induced obese rats.

Paulino Gabriel G   Barbier de la Serre Claire C   Knotts Trina A TA   Oort Pieter J PJ   Newman John W JW   Adams Sean H SH   Raybould Helen E HE  

American journal of physiology. Endocrinology and metabolism 20090203 4


The vagal afferent pathway is important in short-term regulation of food intake, and decreased activation of this neural pathway with long-term ingestion of a high-fat diet may contribute to hyperphagic weight gain. We tested the hypothesis that expression of genes encoding receptors for orexigenic factors in vagal afferent neurons are increased by long-term ingestion of a high-fat diet, thus supporting orexigenic signals from the gut. Obesity-prone (DIO-P) rats fed a high-fat diet showed increa  ...[more]

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