Ontology highlight
ABSTRACT:
SUBMITTER: Schlosser G
PROVIDER: S-EPMC2671077 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Developmental biology 20080520 1
Genes of the Eya family and of the Six1/2 subfamily are expressed throughout development of vertebrate cranial placodes and are required for their differentiation into ganglia and sense organs. How they regulate placodal neurogenesis, however, remains unclear. Through loss of function studies in Xenopus we show that Eya1 and Six1 are required for neuronal differentiation in all neurogenic placodes. The effects of overexpression of Eya1 or Six1 are dose dependent. At higher levels, Eya1 and Six1 ...[more]