Ontology highlight
ABSTRACT:
SUBMITTER: Pino MS
PROVIDER: S-EPMC2671341 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Pino Maria Simona MS Mino-Kenudson Mari M Wildemore Bernadette Mandes BM Ganguly Aniruddha A Batten Julie J Sperduti Isabella I Iafrate Anthony John AJ Chung Daniel C DC
The Journal of molecular diagnostics : JMD 20090326 3
Lynch syndrome is caused by germline mutations in DNA mismatch repair (MMR) genes. Both microsatellite instability (MSI) testing and immunohistochemical analyses (IHC) of colon cancers are valuable diagnostic strategies for Lynch syndrome. We sought to determine whether these markers of MMR deficiency were also detectable in pre-cancerous colorectal adenomas. Fifteen subjects with a germline MMR gene mutation who had 44 adenomas removed during surveillance colonoscopy were identified. MSI testin ...[more]