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International course on emerging viruses in the Amazon region.

ABSTRACT: The international course Emerging Viruses: Global Approaches and Specificities of the Amazon Region was held in Porto Velho, Rondonia, Brazil, November 17-December 7, 2007. Organized as part of the Amsud-Pasteur research collaboration program (sponsored by Institut Pasteur), the course was held there primarily because Rondonia State is located in the Amazon region, a particular environment in which new viruses could emerge as a consequence of ecologic changes brought about by exploration and other human activities.

SUBMITTER: do-Vale-Gomes AL

PROVIDER: S-EPMC2671423 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature

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International course on emerging viruses in the Amazon region.

do-Vale-Gomes Ana Lisa AL Magalhães Cintia C Melo Fernando F Inga Rocio R Gadelha Sandra R SR

Emerging infectious diseases 20090401 4

The international course Emerging Viruses: Global Approaches and Specificities of the Amazon Region was held in Porto Velho, Rondonia, Brazil, November 17-December 7, 2007. Organized as part of the Amsud-Pasteur research collaboration program (sponsored by Institut Pasteur), the course was held there primarily because Rondonia State is located in the Amazon region, a particular environment in which new viruses could emerge as a consequence of ecologic changes brought about by exploration and oth ...[more]

PMID: 19331725

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Project description:BackgroundHepatitis B virus (HBV) and hepatitis D virus (HDV) represent important public health problems in the Western Amazon region with reported cases of fulminant hepatitis. This cross sectional study describes HBV and HDV genotypes circulating in the Brazilian Amazon region.MethodsHBsAg positive individuals (n = 224) were recruited in Manaus/Amazonas State (130 blood donors from the Hematology and Hemotherapy Foundation from Amazonas/HEMOAM; 60 subjects from outpatient clinic) and in Eirunepe city (n = 34) from 2003-2009. Most participants (n = 153) lived in Manaus, 63 were from 20 remote isolated municipalities, 8 lived outside Amazonas State. Genotyping was based on PCR products: HBV genotype A-F specific primers, restricted length polymorphism for HDV. HDV isolates were directly sequenced (delta antigen 405 nucleotide fragment) and phylogenetic analysis performed (MEGA; neighbor-joining, Kimura's two parameter).ResultsMost participants were young adult males and HBV mono-infection predominated (70.5%, 158/224). Among blood donors, outpatient subjects and individuals from Eirunepe, HBV/A prevailed followed by HBV/D and F (p > 0.05). HBV/A was more frequent in blood donors (p < 0.05). HBV-HDV coinfection rate was 8.5% in blood donors (11/130), 65.0% (39/60) in outpatient subjects and 47.0% (16/34) in individuals from Eirunepe. Compared to blood donors, coinfection was higher in outpatient subjects (65.0% versus 8.5%; RR = 5.0; CI 3.4-7.9; p < 0.0001) and in subjects from Eirunepe (47.0% versus 8.5%; RR = 5.5; CI 3.0-9.9; p < 0.0001). HBV-HDV coinfection rates were higher in patients from highly endemic remote cities. Only HDV genotype 3 was detected, HBV/F-HDV/3 predominated (20/38; 52.7%), followed by HBV/A-HDV/3 (31.6%; 12/38) and HBV/D-HDV/3 (15.8%; 6/38).ConclusionsThe description of HBV and HDV genotypes circulating in the western Amazon can contribute to a better understanding of their relevance on the regional epidemics. These infections are highly endemic in the Amazon where their control is challenged by its vast territorial dimension with small, hard-to-reach municipalities dispersed into the jungle and populated by diverse ethnic groups.

Dataset Information

International course on emerging viruses in the Amazon region.

Publications

International course on emerging viruses in the Amazon region.

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