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Assessing the outcomes of prolonged cessation-induction and aid-to-cessation trials: floating prolonged abstinence.


ABSTRACT:

Introduction

A Society for Research on Nicotine and Tobacco working group recommended outcome measures for cessation-induction trials and aid-to-cessation trials. Cessation-induction trials aim to motivate unwilling quitters to make a quit attempt. Aid-to-cessation trials give either medication or behavioral interventions to increase the rate at which willing quitters succeed in their attempts. Nicotine-assisted reduction programs combine features of both types of interventions by giving nicotine replacement to unwilling quitters. Treatment can be prolonged more than a year, quit attempts can occur and succeed early or late in the program, and renewed quit attempts are an inherent part of the program. Conventional outcome measures are tied to a fixed but arbitrary point in follow-up and cannot capture the true outcome: Prolonged cessation anchored to the point at which a person makes a successful quit attempt.

Discussion

We propose that the outcome should be counted from the successful quit attempt that began during the treatment period and continues for a defined period, ideally 6 months. In particular, if a trial compared a short reduction program with a long reduction program, it would not be possible to obtain an unbiased assessment of the outcome of such a trial using a measure tied to a fixed point in follow-up. Floating prolonged abstinence could provide such an assessment and is suitable for either prolonged cessation-induction trial or combined cessation-induction and aid-to-cessation trials.

SUBMITTER: Aveyard P 

PROVIDER: S-EPMC2671463 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature

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Assessing the outcomes of prolonged cessation-induction and aid-to-cessation trials: floating prolonged abstinence.

Aveyard Paul P   Wang Dechao D   Connock Martin M   Fry-Smith Anne A   Barton Pelham P   Moore David D  

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20090403 5


<h4>Introduction</h4>A Society for Research on Nicotine and Tobacco working group recommended outcome measures for cessation-induction trials and aid-to-cessation trials. Cessation-induction trials aim to motivate unwilling quitters to make a quit attempt. Aid-to-cessation trials give either medication or behavioral interventions to increase the rate at which willing quitters succeed in their attempts. Nicotine-assisted reduction programs combine features of both types of interventions by giving  ...[more]

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