Ontology highlight
ABSTRACT:
SUBMITTER: Zakharian E
PROVIDER: S-EPMC2671608 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Zakharian Eleonora E Thyagarajan Baskaran B French Robert J RJ Pavlov Evgeny E Rohacs Tibor T
PloS one 20090430 4
Polyphosphate (polyP) is an inorganic polymer built of tens to hundreds of phosphates, linked by high-energy phosphoanhydride bonds. PolyP forms complexes and modulates activities of many proteins including ion channels. Here we investigated the role of polyP in the function of the transient receptor potential melastatin 8 (TRPM8) channel. Using whole-cell patch-clamp and fluorescent calcium measurements we demonstrate that enzymatic breakdown of polyP by exopolyphosphatase (scPPX1) inhibits cha ...[more]