Ontology highlight
ABSTRACT:
SUBMITTER: Buettner C
PROVIDER: S-EPMC2671848 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Buettner Christoph C Muse Evan D ED Cheng Andrew A Chen Linghong L Scherer Thomas T Pocai Alessandro A Su Kai K Cheng Bob B Li Xiasong X Harvey-White Judith J Schwartz Gary J GJ Kunos George G Rossetti Luciano L Buettner Christoph C
Nature medicine 20080601 6
Leptin (encoded by Lep) controls body weight by regulating food intake and fuel partitioning. Obesity is characterized by leptin resistance and increased endocannabinoid tone. Here we show that leptin infused into the mediobasal hypothalamus (MBH) of rats inhibits white adipose tissue (WAT) lipogenesis, which occurs independently of signal transducer and activator of transcription-3 (STAT3) signaling. Correspondingly, transgenic inactivation of STAT3 signaling by mutation of the leptin receptor ...[more]