Ontology highlight
ABSTRACT:
SUBMITTER: Norman RX
PROVIDER: S-EPMC2671991 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Norman Ryan X RX Ko Hyuk W HW Huang Viola V Eun Christine M CM Abler Lisa L LL Zhang Zhen Z Sun Xin X Eggenschwiler Jonathan T JT
Human molecular genetics 20090312 10
Tubby-like protein 3 (TULP3) is required for proper embryonic development in mice. Disruption of mouse Tulp3 results in morphological defects in the embryonic craniofacial regions, the spinal neural tube and the limbs. Here, we show that TULP3 functions as a novel negative regulator of Sonic hedgehog (Shh) signaling in the mouse. In Tulp3 mutants, ventral cell types in the lumbar neural tube, which acquire their identities in response to Shh signaling, are ectopically specified at the expense of ...[more]