Ontology highlight
ABSTRACT:
SUBMITTER: Tishkoff SA
PROVIDER: S-EPMC2672153 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Tishkoff Sarah A SA Reed Floyd A FA Ranciaro Alessia A Voight Benjamin F BF Babbitt Courtney C CC Silverman Jesse S JS Powell Kweli K Mortensen Holly M HM Hirbo Jibril B JB Osman Maha M Ibrahim Muntaser M Omar Sabah A SA Lema Godfrey G Nyambo Thomas B TB Ghori Jilur J Bumpstead Suzannah S Pritchard Jonathan K JK Wray Gregory A GA Deloukas Panos P
Nature genetics 20061210 1
A SNP in the gene encoding lactase (LCT) (C/T-13910) is associated with the ability to digest milk as adults (lactase persistence) in Europeans, but the genetic basis of lactase persistence in Africans was previously unknown. We conducted a genotype-phenotype association study in 470 Tanzanians, Kenyans and Sudanese and identified three SNPs (G/C-14010, T/G-13915 and C/G-13907) that are associated with lactase persistence and that have derived alleles that significantly enhance transcription fro ...[more]