Ontology highlight
ABSTRACT:
SUBMITTER: Souroullas GP
PROVIDER: S-EPMC2672304 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Souroullas George P GP Salmon Jessica M JM Sablitzky Fred F Curtis David J DJ Goodell Margaret A MA
Cell stem cell 20090201 2
Scl and Lyl1 encode two related basic-helix-loop-helix transcription factors implicated in T cell acute lymphoblastic leukemia. Previous studies showed that Scl is essential for embryonic and adult erythropoiesis, while Lyl1 is important for B cell development. Single-knockout mice have not revealed an essential function for Scl or Lyl1 in adult hematopoietic stem cells (HSCs). To determine if maintenance of HSCs in single-knockout mice is due to functional redundancy, we generated Lyl1;Scl-cond ...[more]