Ontology highlight
ABSTRACT:
SUBMITTER: Mintern JD
PROVIDER: S-EPMC2672519 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Mintern Justine D JD Bedoui Sammy S Davey Gayle M GM Moffat Jessica M JM Doherty Peter C PC Turner Stephen J SJ
Proceedings of the National Academy of Sciences of the United States of America 20090403 16
Antigen expressed as MHC Class I glycoprotein (pMHCI) complexes on dendritic cells is the primary driver of CD8(+) T cell clonal expansion and differentiation. As we seek to define the molecular differences between acutely stimulated cytotoxic T lymphocyte (CTL) effectors and long-lived memory T cells, it is essential that we understand the duration of in vivo pMHCI persistence. Although infectious influenza A virus is readily cleared by mammalian hosts, that does not necessarily mean that all i ...[more]