Ontology highlight
ABSTRACT:
SUBMITTER: Riley CJ
PROVIDER: S-EPMC2672909 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Riley Christopher J CJ Engelhardt Kevin P KP Saldanha Jose W JW Qi Wenqing W Cooke Laurence S LS Zhu Yingting Y Narayan Satya T ST Shakalya Kishore K Croce Kimiko Della KD Georgiev Ivan G IG Nagle Raymond B RB Garewal Harinder H Von Hoff Daniel D DD Mahadevan Daruka D
Cancer research 20090224 5
Pancreatic ductal adenocarcinoma (PDA) is a lethal disease, with surgery being the only curative modality for localized disease, and gemcitabine with or without erlotinib remains the standard of therapy for unresectable or metastatic disease. CEACAM6 is overexpressed in human PDA independent of stage or grade and causes anoikis resistance when dysregulated. Because murine monoclonal antibody 13-1 possesses target-specific cytotoxicity in human PDA cell lines, we designed a humanized anti-CEACAM6 ...[more]