Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss.
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ABSTRACT:
SUBMITTER: Halassa MM
PROVIDER: S-EPMC2673052 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Publications
Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss.
Halassa Michael M MM Florian Cedrick C Fellin Tommaso T Munoz James R JR Lee So-Young SY Abel Ted T Haydon Philip G PG Frank Marcos G MG
Neuron 20090101 2
Astrocytes modulate neuronal activity by releasing chemical transmitters via a process termed gliotransmission. The role of this process in the control of behavior is unknown. Since one outcome of SNARE-dependent gliotransmission is the regulation of extracellular adenosine and because adenosine promotes sleep, we genetically inhibited the release of gliotransmitters and asked if astrocytes play an unsuspected role in sleep regulation. Inhibiting gliotransmission attenuated the accumulation of s ...[more]
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