Ontology highlight
ABSTRACT:
SUBMITTER: Ganley IG
PROVIDER: S-EPMC2673298 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20090303 18
Autophagy is a degradative process that recycles long-lived and faulty cellular components. It is linked to many diseases and is required for normal development. ULK1, a mammalian serine/threonine protein kinase, plays a key role in the initial stages of autophagy, though the exact molecular mechanism is unknown. Here we report identification of a novel protein complex containing ULK1 and two additional protein factors, FIP200 and ATG13, all of which are essential for starvation-induced autophag ...[more]