Ontology highlight
ABSTRACT:
SUBMITTER: Gao J
PROVIDER: S-EPMC2673483 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
Cell metabolism 20090301 3
The mechanisms that allow the body to sense iron levels in order to maintain iron homeostasis are unknown. Patients with the most common form of hereditary iron overload have mutations in the hereditary hemochromatosis protein HFE. They have lower levels of hepcidin than unaffected individuals. Hepcidin, a hepatic peptide hormone, negatively regulates iron efflux from the intestines into the blood. We report two hepatic cell lines, WIF-B cells and HepG2 cells transfected with HFE, where hepcidin ...[more]