Ontology highlight
ABSTRACT:
SUBMITTER: Marijanovic Z
PROVIDER: S-EPMC2673690 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Marijanovic Zrinka Z Caputo Anna A Campana Vincenza V Zurzolo Chiara C
PLoS pathogens 20090508 5
Prion diseases are fatal, neurodegenerative disorders in humans and animals and are characterized by the accumulation of an abnormally folded isoform of the cellular prion protein (PrP(C)), denoted PrP(Sc), which represents the major component of infectious scrapie prions. Characterization of the mechanism of conversion of PrP(C) into PrP(Sc) and identification of the intracellular site where it occurs are among the most important questions in prion biology. Despite numerous efforts, both of the ...[more]