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Photoregulated release of caged anticancer drugs from gold nanoparticles.

ABSTRACT: An anticancer drug (5-fluorouracil) was conjugated to the surface of gold nanoparticles through a photocleavable o-nitrobenzyl linkage. In this system, the particle serves as both cage and carrier for the therapeutic, providing a nontoxic conjugate that effectively releases the payload upon long wavelength UV irradiation.

SUBMITTER: Agasti SS

PROVIDER: S-EPMC2673701 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature

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Photoregulated release of caged anticancer drugs from gold nanoparticles.

Agasti Sarit S SS Chompoosor Apiwat A You Chang-Cheng CC Ghosh Partha P Kim Chae Kyu CK Rotello Vincent M VM

Journal of the American Chemical Society 20090401 16

An anticancer drug (5-fluorouracil) was conjugated to the surface of gold nanoparticles through a photocleavable o-nitrobenzyl linkage. In this system, the particle serves as both cage and carrier for the therapeutic, providing a nontoxic conjugate that effectively releases the payload upon long wavelength UV irradiation. ...[more]

PMID: 19351115

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