Ontology highlight
ABSTRACT:
SUBMITTER: Bachelder EM
PROVIDER: S-EPMC2673804 | biostudies-literature | 2008 Aug
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20080717 32
Dextran, a biocompatible, water-soluble polysaccharide, was modified at its hydroxyls with acetal moieties such that it became insoluble in water but freely soluble in common organic solvents enabling its use in the facile preparation of acid-sensitive microparticles. These particles degrade in a pH-dependent manner: FITC-dextran was released with a half-life at 37 degrees C of 10 h at pH 5.0 compared to a half-life of approximately 15 days at pH 7.4. Both hydrophobic and hydrophilic cargoes wer ...[more]