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The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus.


ABSTRACT: SLE, a chronic, multisystem autoimmune disorder with a broad range of symptoms, involves defective B cell selection and elimination of self-reactive B cells. B lymphocyte stimulator (BLyS), a soluble ligand of the TNF cytokine family, is a prominent factor in B cell differentiation, homeostasis, and selection. BLyS levels affect survival signals and selective apoptosis of autoantibody-producing B cells. High levels of BLyS may relax B cell selection and contribute to autoantibody production, exacerbating the SLE disease state. This review discusses the mechanism of BLyS action on B cells, its role in SLE, and specific targeting of BLyS in the treatment of SLE.

SUBMITTER: Cancro MP 

PROVIDER: S-EPMC2673851 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature

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The role of B lymphocyte stimulator (BLyS) in systemic lupus erythematosus.

Cancro Michael P MP   D'Cruz David P DP   Khamashta Munther A MA  

The Journal of clinical investigation 20090501 5


SLE, a chronic, multisystem autoimmune disorder with a broad range of symptoms, involves defective B cell selection and elimination of self-reactive B cells. B lymphocyte stimulator (BLyS), a soluble ligand of the TNF cytokine family, is a prominent factor in B cell differentiation, homeostasis, and selection. BLyS levels affect survival signals and selective apoptosis of autoantibody-producing B cells. High levels of BLyS may relax B cell selection and contribute to autoantibody production, exa  ...[more]

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