Ontology highlight
ABSTRACT:
SUBMITTER: Cancro MP
PROVIDER: S-EPMC2673851 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Cancro Michael P MP D'Cruz David P DP Khamashta Munther A MA
The Journal of clinical investigation 20090501 5
SLE, a chronic, multisystem autoimmune disorder with a broad range of symptoms, involves defective B cell selection and elimination of self-reactive B cells. B lymphocyte stimulator (BLyS), a soluble ligand of the TNF cytokine family, is a prominent factor in B cell differentiation, homeostasis, and selection. BLyS levels affect survival signals and selective apoptosis of autoantibody-producing B cells. High levels of BLyS may relax B cell selection and contribute to autoantibody production, exa ...[more]