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Genetic variation and atherosclerosis.


ABSTRACT: A family history of atherosclerosis is independently associated with an increased incidence of cardiovascular events. The genetic factors underlying the importance of inheritance in atherosclerosis are starting to be understood. Genetic variation, such as mutations or common polymorphisms has been shown to be involved in modulation of a range of risk factors, such as plasma lipoprotein levels, inflammation and vascular calcification. This review presents examples of present studies of the role of genetic polymorphism in atherosclerosis.

SUBMITTER: Biros E 

PROVIDER: S-EPMC2674308 | biostudies-literature | 2008 Mar

REPOSITORIES: biostudies-literature

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Genetic variation and atherosclerosis.

Biros Erik E   Karan Mirko M   Golledge Jonathan J  

Current genomics 20080301 1


A family history of atherosclerosis is independently associated with an increased incidence of cardiovascular events. The genetic factors underlying the importance of inheritance in atherosclerosis are starting to be understood. Genetic variation, such as mutations or common polymorphisms has been shown to be involved in modulation of a range of risk factors, such as plasma lipoprotein levels, inflammation and vascular calcification. This review presents examples of present studies of the role o  ...[more]

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