Ontology highlight
ABSTRACT:
SUBMITTER: Swisher EM
PROVIDER: S-EPMC2674369 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Swisher Elizabeth M EM Sakai Wataru W Karlan Beth Y BY Wurz Kaitlyn K Urban Nicole N Taniguchi Toshiyasu T
Cancer research 20080401 8
Although ovarian carcinomas with mutated BRCA1 or BRCA2 are sensitive to platinum compounds, such carcinomas eventually develop platinum resistance. Previously, we showed that acquired resistance to cisplatin in BRCA2-mutated tumors can be mediated by secondary intragenic mutations in BRCA2 that restore the wild-type BRCA2 reading frame. Here, we show that secondary mutations of BRCA1 also occur in BRCA1-mutated ovarian cancer with platinum resistance. We evaluated nine recurrent BRCA1-mutated o ...[more]