Expression quantitative trait loci mapping with multivariate sparse partial least squares regression.

ABSTRACT: Expression quantitative trait loci (eQTL) mapping concerns finding genomic variation to elucidate variation of expression traits. This problem poses significant challenges due to high dimensionality of both the gene expression and the genomic marker data. We propose a multivariate response regression approach with simultaneous variable selection and dimension reduction for the eQTL mapping problem. Transcripts with similar expression are clustered into groups, and their expression profiles are viewed as a multivariate response. Then, we employ our recently developed sparse partial least-squares regression methodology to select markers associated with each cluster of genes. We demonstrate with extensive simulations that our eQTL mapping with multivariate response sparse partial least-square

SUBMITTER: Chun H 

PROVIDER: S-EPMC2674843 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature