Ontology highlight
ABSTRACT:
SUBMITTER: Dror Michaelson M
PROVIDER: S-EPMC2674960 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Dror Michaelson M M Regan M M MM Oh W K WK Kaufman D S DS Olivier K K Michaelson S Z SZ Spicer B B Gurski C C Kantoff P W PW Smith M R MR
Annals of oncology : official journal of the European Society for Medical Oncology 20090501 5
<h4>Background</h4>This study explored the efficacy and tolerability of sunitinib, an inhibitor of tyrosine kinase receptors, in men with castration-resistant prostate cancer (CRPC).<h4>Methods</h4>Men with no prior chemotherapy (group A) and men with docetaxel (Taxotere)-resistant prostate cancer (group B) were treated with sunitinib. The primary end point was confirmed 50% prostate-specific antigen (PSA) decline. Secondary end points included objective response rate and safety. Serum-soluble b ...[more]