Plug-based microfluidics with defined surface chemistry to miniaturize and control aggregation of amyloidogenic peptides.
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ABSTRACT:
SUBMITTER: Meier M
PROVIDER: S-EPMC2675571 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Publications
Plug-based microfluidics with defined surface chemistry to miniaturize and control aggregation of amyloidogenic peptides.
Meier Matthias M Kennedy-Darling Julia J Choi Se Hoon SH Norstrom Eric M EM Sisodia Sangram S SS Ismagilov Rustem F RF
Angewandte Chemie (International ed. in English) 20090101 8
Small with control: For miniaturization of protein aggregation experiments the interfacial chemistry must be controlled to avoid protein aggregation caused by interfacial adsorption. Plug-based microfluidics with defined surface chemistry (see schematic picture) can then be used to perform hundreds of aggregation experiments with volume-limited samples, such as cerebrospinal fluid from mice. ...[more]
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