Plug-based microfluidics with defined surface chemistry to miniaturize and control aggregation of amyloidogenic peptides.

ABSTRACT: Small with control: For miniaturization of protein aggregation experiments the interfacial chemistry must be controlled to avoid protein aggregation caused by interfacial adsorption. Plug-based microfluidics with defined surface chemistry (see schematic picture) can then be used to perform hundreds of aggregation experiments with volume-limited samples, such as cerebrospinal fluid from mice.

SUBMITTER: Meier M 

PROVIDER: S-EPMC2675571 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature