Ontology highlight
ABSTRACT:
SUBMITTER: Pacanowski MA
PROVIDER: S-EPMC2675574 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Pacanowski M A MA Gong Y Y Cooper-Dehoff R M RM Schork N J NJ Shriver M D MD Langaee T Y TY Pepine C J CJ Johnson J A JA
Clinical pharmacology and therapeutics 20080709 6
Numerous studies have demonstrated that beta(1)- and beta(2)-adrenergic receptor gene (ADRB1 and ADRB2) variants influence cardiovascular risk and beta-blocker responses in hypertension and heart failure. We evaluated the relationship between ADRB1 and ADRB2 haplotypes, cardiovascular risk (death, nonfatal myocardial infarction (MI), and nonfatal stroke), and atenolol-based vs. verapamil sustained-release (SR)-based antihypertensive therapy in 5,895 coronary artery disease (CAD) patients. After ...[more]