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ABSTRACT:
SUBMITTER: Verma SK
PROVIDER: S-EPMC2675579 | biostudies-literature | 2009 May
REPOSITORIES: biostudies-literature
Verma Sunil Kumar SK Jaiswal Mamta M Kumar Neeraj N Parikh Amit A Nandicoori Vinay Kumar VK Prakash Balaji B
Acta crystallographica. Section F, Structural biology and crystallization communications 20090424 Pt 5
GlmU is a bifunctional enzyme that catalyzes the final two steps in the biosynthesis of UDP-GlcNAc. Crystals of GlmU from Mycobacterium tuberculosis obtained using ammonium sulfate as a precipitant diffracted poorly (to 3.4 A resolution) and displayed an unusually high solvent content (>80%) with sparse crystal packing that resulted in large solvent channels. With one molecule per asymmetric unit, the monomers from three neighbouring asymmetric units related by the crystal threefold formed a bio ...[more]