Nucleosomes can invade DNA territories occupied by their neighbors.
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ABSTRACT:
SUBMITTER: Engeholm M
PROVIDER: S-EPMC2675935 | biostudies-literature | 2009 Feb
REPOSITORIES: biostudies-literature
Publications
Nucleosomes can invade DNA territories occupied by their neighbors.
Engeholm Maik M de Jager Martijn M Flaus Andrew A Brenk Ruth R van Noort John J Owen-Hughes Tom T
Nature structural & molecular biology 20090201 2
Nucleosomes are the fundamental subunits of eukaryotic chromatin. They are not static entities, but can undergo a number of dynamic transitions, including spontaneous repositioning along DNA. As nucleosomes are spaced close together within genomes, it is likely that on occasion they approach each other and may even collide. Here we have used a dinucleosomal model system to show that the 147-base-pair (bp) DNA territories of two nucleosomes can overlap extensively. In the situation of an overlap ...[more]
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