Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA/1j mice.

ABSTRACT: One approach to understanding common human diseases is to determine the genetic defects responsible for similar diseases in animal models and place those defective genes in their corresponding biochemical pathways. Our laboratory is working with an animal model for human rheumatoid arthritis called collagen-induced arthritis (CIA). We are particularly interested in determining the location of disease-predisposing loci. To that end, we performed experiments to localize susceptibility loci for CIA in an F2 cross between the highly susceptible mouse strain DBA/1j and the highly resistant mouse strain SWR/j. Specifically, a quantitative trait locus analysis was performed to localize regions of the mouse genome responsible for susceptibility/severity to CIA. One susceptibility locus, Cia1 in th

SUBMITTER: McIndoe RA 

PROVIDER: S-EPMC26762 | biostudies-literature | 1999 Mar

REPOSITORIES: biostudies-literature