Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma.
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ABSTRACT:
SUBMITTER: Liu ZM
PROVIDER: S-EPMC2676441 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
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Hepatitis B virus infection contributes to oxidative stress in a population exposed to aflatoxin B1 and high-risk for hepatocellular carcinoma.
Liu Zhi-Ming ZM Li Le-Qun LQ Peng Min-Hao MH Liu Tang-Wei TW Qin Zhong Z Guo Ya Y Xiao Kai-Yin KY Ye Xin-Ping XP Mo Xin-Shao XS Qin Xue X Li Shan S Yan Lu-Nan LN Shen Han-Ming HM Wang LianWen L Wang Qiao Q Wang Kai-bo KB Liang Ren-xiang RX Wei Zong-liang ZL Ong Choon Nam CN Santella Regina M RM Peng Tao T
Cancer letters 20080215 2
Biomarkers of hepatitis B virus (HBV) infection, aflatoxin B1 (AFB1) exposure and oxidative stress were detected in 71 hepatocellular carcinoma (HCC) patients and 694 controls from southern China. Plasma level of AFB1-albumin-adducts (AAA) and protein carbonyl content (PCC) were significantly higher in the 71 HCC cases than in any age/gender matched HBV sero-status groups (p<0.001). HCC patients positive for the p53-249 G-T mutation had a marginally higher level of PCC than those negative for th ...[more]
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