Ontology highlight
ABSTRACT:
SUBMITTER: Chami M
PROVIDER: S-EPMC2676567 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Chami Mounia M Oulès Bénédicte B Szabadkai György G Tacine Rachida R Rizzuto Rosario R Paterlini-Bréchot Patrizia P
Molecular cell 20081201 5
Among the new players at the endoplasmic reticulum (ER)-mitochondria interface regulating interorganelle calcium signaling, those specifically involved during ER stress are not known at present. We report here that the truncated variant of the sarcoendoplasmic reticulum Ca(2+)-ATPase 1 (S1T) amplifies ER stress through the PERK-eIF2alpha-ATF4-CHOP pathway. S1T, which is localized in the ER-mitochondria microdomains, determines ER Ca(2+) depletion due to increased Ca(2+) leak, an increased number ...[more]